TRNK (karboksimetiluridin34-5-O)-metiltransferaza
(Preusmjereno sa stranice ALKBH8)
TRNK (karboksimetiluridin34-5-O)-metiltransferaza (EC 2.1.1.229, ALKBH8, ABH8, Trm9, tRNK metiltransferaza 9) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (karboksimetiluridin34-5-O)-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| TRNK (karboksimetiluridin34-5-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.229 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + karboksimetiluridin34 u tRNK S-adenozil-L-homocistein + 5-(2-metoksi-2-oksoetil)uridin34 u tRNK
Ovaj enzim katalizuje posttranslacionu modifikaciju uridinskih ostataka u pokretnoj poziciji 34 antikodonske petlje tRNK.
Reference uredi
- ↑ Fu, D., Brophy, J.A., Chan, C.T., Atmore, K.A., Begley, U., Paules, R.S., Dedon, P.C., Begley, T.J. and Samson, L.D. (2010). „Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival”. Mol. Cell Biol. 30: 2449-2459. PMID 20308323.
- ↑ Songe-Møller, L., van den Born, E., Leihne, V., Vågbø, C.B., Kristoffersen, T., Krokan, H.E., Kirpekar, F., Falnes, P.Ø. and Klungland, A. (2010). „Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding”. Mol. Cell Biol. 30: 1814-1827. PMID 20123966.
- ↑ Kalhor, H.R. and Clarke, S. (2003). „Novel methyltransferase for modified uridine residues at the wobble position of tRNA”. Mol. Cell Biol. 23: 9283-9292. PMID 14645538.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.