Dolihil-P-Man:Man5GlcNAc2-PP-dolihol alfa-1,3-manoziltransferaza
Dolihil-P-Man:Man5GlcNAc2-PP-dolihol alfa-1,3-manoziltransferaza (EC 2.4.1.258, Man5GlcNAc2-PP-Dol manoziltransferaza, ALG3, dolihil-P-Man:Man(5)GlcNAc(2)-PP-dolihil manoziltransferaza, Not56-slični protein, Alg3 alfa-1,3-manozil transferaza, Dol-P-Man:Man5GlcNAc2-PP-Dol alfa-1,3-manoziltransferaza) je enzim sa sistematskim imenom dolihil beta-D-manozil fosfat:D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol alfa-1,3-manoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dolihil-P-Man:Man5GlcNAc2-PP-dolihol alfa-1,3-manoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.258 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- dolihil beta-D-manozil fosfat + D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->3)-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol + dolihil fosfat
Tokom formiranja N-glikozilnih veza glikoproteina dolazi do uređivanja sklopa rasprostanjenih oligosaharida sa Glc3Man9GlcNAc2 osnovom na lipidnom nosiocu dolihil difosfatu.
Reference uredi
- ↑ Sharma, C.B., Knauer, R. and Lehle, L. (2001). „Biosynthesis of lipid-linked oligosaccharides in yeast: the ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase”. Biol. Chem. 382: 321-328. PMID 11308030.
- ↑ Cipollo, J.F. and Trimble, R.B. (2000). „The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Δalg9 mutant reveals a regulatory role for the Alg3p α1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing”. J. Biol. Chem. 275: 4267-4277. PMID 10660594.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.