9,12-Oktadekadienoat 8-hidroperoksidna 8R-izomeraza
9,12-Oktadekadienoat 8-hidroperoksidna 8R-izomeraza (EC 5.4.4.5, 5,8-LDS (bifunkcionalan enzim), 5,8-linoleat diolna sintaza (bifunkcionalani enzim), 8-hidroperoksidna izomeraza, (8R,9Z,12Z)-8-hidroperoksi-9,12-octadekadienoatna mutaza (formira (5S,8R,9Z,12Z)-5,8-dihidroksi-9,12-oktadekadienoat), PpoA) je enzim sa sistematskim imenom (8R,9Z,12Z)-8-hidroperoksioktadeka-9,12-dienoat hidroksimutaza (formira (5S,8R,9Z,12Z)-5,8-dihidroksioktadeka-9,12-dienoat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 9,12-Oktadekadienoat 8-hidroperoksidna 8R-izomeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.4.5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (8R,9Z,12Z)-8-hidroperoksioktadeka-9,12-dienoat (5S,8R,9Z,12Z)-5,8-dihidroksioktadeka-9,12-dienoat
Ovaj enzim sadrži hem.
Reference
uredi- ↑ Hoffmann, I., Jerneren, F., Garscha, U. and Oliw, E.H. (2011). „Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase”. Arch. Biochem. Biophys. 506: 216-222. PMID 21130068.
- ↑ Jerneren, F., Garscha, U., Hoffmann, I., Hamberg, M. and Oliw, E.H. (2010). „Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus”. Biochim. Biophys. Acta 1801: 503-507. PMID 20045744.
- ↑ Brodhun, F., Gobel, C., Hornung, E. and Feussner, I. (2009). „Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P450”. J. Biol. Chem. 284: 11792-11805. PMID 19286665.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.