8-Amino-7-oksononanoat sintaza
(Preusmjereno sa stranice 7-keto-8-aminopelargonsko kiselinska sintetaza)
8-amino-7-oksononanoat sintaza (EC 2.3.1.47, 7-keto-8-aminopelargonsko kiselinska sintetaza, 7-keto-8-aminopelargonska sintetaza, 8-amino-7-oksopelargonatna sintaza) je enzim sa sistematskim imenom 6-karboksiheksanoil-KoA:L-alanin C-karboksiheksanoiltransferaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 8-amino-7-oksononanoat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.47 | ||||||||
| CAS broj | 9075-61-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 6-karboksiheksanoil-KoA + L-alanin 8-amino-7-oksononanoat + KoA + CO2
Ovaj enzim je piridoksal-fosfatni protein.
Reference uredi
- ↑ Eisenberg, M.A. and Star, C. (1968). „Synthesis of 7-oxo-8-aminopelargonic acid, a biotin vitamer, in cell-free extracts of Escherichia coli biotin auxotrophs”. J. Bacteriol. 96: 1291-1297. PMID 4879561.
- ↑ Alexeev, D., Alexeeva, M., Baxter, R.L., Campopiano, D.J., Webster, S.P. and Sawyer, L. (1998). „The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme”. J. Mol. Biol. 284: 401-419. PMID 9813126.
- ↑ Ploux, O., Breyne, O., Carillon, S. and Marquet, A. (1999). „Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5′-phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies”. Eur. J. Biochem. 259: 63-70. PMID 9914476.
- ↑ Webster, S.P. (2000). „, Alexeev. D., Campopiano, D.J., Watt, R.M., Alexeeva, M., Sawyer, L. and Baxter, R. Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies”. Biochemistry 39: 516-528. PMID 10642176.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.