Linoleat 8R-lipoksigenaza
(Preusmjereno sa stranice 7,8-LDS (bifunkcionalni enzim))
Linoleat 8R-lipoksigenaza (EC 1.13.11.60, linoleinska kiselina 8R-dioksigenaza, 5,8-LDS (bifunkcionalni enzim), 7,8-LDS (bifunkcionalni enzim), 5,8-linoleat diolna sintaza (bifunkcionalni enzim), 7,8-linoleat diolna sintaza (bifunkcionalni enzim), PpoA) je enzim sa sistematskim imenom linoleat:kiseonik (8R)-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Linoleat 8R-lipoksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.60 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- linoleat + O2 (8R,9Z,12Z)-8-hidroperoksioktadeka-9,12-dienoat
Ovaj enzim sadrži hem. Bifunkcionalni enzim iz Aspergillus nidulans koristi različite hem domene da kataluje dve zasebne reakcije.
Reference uredi
- ↑ Brodhun, F., Gobel, C., Hornung, E. and Feussner, I. (2009). „Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P450”. J. Biol. Chem. 284: 11792-11805. PMID 19286665.
- ↑ Hamberg, M., Zhang, L.-Y., Brodowsky, I.D. and Oliw, E.H. (1994). „Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions”. Arch. Biochem. Biophys. 309: 77-80. PMID 8117115.
- ↑ Garscha, U. and Oliw, E. (2008). „Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase”. Biochem. Biophys. Res. Commun. 373: 579-583. PMID 18586008.
- ↑ Su, C. and Oliw, E.H. (1996). „Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as a novel hemoprotein”. J. Biol. Chem. 271: 14112-14118. PMID 8662736.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.