5-(Karboksiamino)imidazol ribonukleotidna sintaza
5-(Karboksiamino)imidazol ribonukleotidna sintaza (EC 6.3.4.18, N5-CAIR sintetaza, N5-karboksiaminoimidazol ribonukleotidna sintetaza, PurK) je enzim sa sistematskim imenom 5-amino-1-(5-fosfo-D-ribozil)imidazol:ugljen-dioksid ligaza (formira ADP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 5-(Karboksiamino)imidazol ribonukleotidna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.4.18 | ||||||||
| CAS broj | 255379-40-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + 5-amino-1-(5-fosfo-D-ribozil)imidazol + HCO3- ADP + fosfat + 5-karboksiamino-1-(5-fosfo-D-ribozil)imidazol
Kod Escherichia coli, ovaj enzim je neophodan za odvijanje reakcije enzima EC 4.1.1.21.
Reference uredi
- ↑ Meyer, E., Leonard, N.J., Bhat, B., Stubbe, J. and Smith, J.M. (1992). „Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway”. Biochemistry 31: 5022-5032. PMID 1534690.
- ↑ Mueller, E.J., Meyer, E., Rudolph, J., Davisson, V.J. and Stubbe, J. (1994). „N5-Carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli”. Biochemistry 33: 2269-2278. PMID 8117684.
- ↑ Thoden, J.B., Kappock, T.J., Stubbe, J. and Holden, H.M. (1999). „Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily”. Biochemistry 38: 15480-15492. PMID 10569930.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.