4-hidroksimandelat sintaza
4-hidroksimandelat sintaza (EC 1.13.11.46, 4-hidroksifenilpiruvatna dioksigenaza II) je enzim sa sistematskim imenom 4-hidroksifenilpiruvat:kiseonik oksidoreduktaza (dekarboksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 4-hidroksimandelat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.46 | ||||||||
| CAS broj | 280566-04-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4-hidroksifenilpiruvat + O2 4-hidroksimandelat + CO2
Ovaj enzim sadrži Fe2+. On učestvuje u biosintezi vankomicinske grupe glikopeptidnih antibiotika.
Reference uredi
- ↑ Choroba, O.W., Williams, D.H. and Spencer, J.B. (2000). „Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine”. J. Am. Chem. Soc. 122: 5389-5390.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.