4-Hidroksibutanoil-KoA dehidrataza
4-Hidroksibutanoil-KoA dehidrataza (EC 4.2.1.120) je enzim sa sistematskim imenom 4-hidroksibutanoil-KoA hidrolijaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 4-Hidroksibutanoil-KoA dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.120 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4-hidroksibutanoil-KoA but-3-enoil-KoA + H2O
Ovaj enzim sadrži FAD i [4Fe-4S], gvožđe-sumporni kluster.
Reference uredi
- ↑ Bartsch, R.G. and Barker, H.A. (1961). „A vinylacetyl isomerase from Clostridium kluyveri”. Arch. Biochem. Biophys. 92: 122-132. PMID 13687513.
- ↑ Scherf, U., Sohling, B., Gottschalk, G., Linder, D. and Buckel, W. (1994). „Succinate-ethanol fermentation in Clostridium kluyveri: purification and characterisation of 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA Δ3-Δ2-isomerase”. Arch. Microbiol. 161: 239-245. PMID 8161284.
- ↑ Scherf, U. and Buckel, W. (1993). „Purification and properties of an iron-sulfur and FAD-containing 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA Δ3-Δ2-isomerase from Clostridium aminobutyricum”. Eur. J. Biochem. 215: 421-429. PMID 8344309.
- ↑ Muh, U., Cinkaya, I., Albracht, S.P. and Buckel, W. (1996). „4-Hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum: characterization of FAD and iron-sulfur clusters involved in an overall non-redox reaction”. Biochemistry 35: 11710-11718. PMID 8794752.
- ↑ Berg, I.A., Kockelkorn, D., Buckel, W. and Fuchs, G. (2007). „A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea”. Science 318: 1782-1786. PMID 18079405.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.