Pseudooksinikotin oksidaza
(Preusmjereno sa stranice 4-(methylamino)-1-(pyridin-3-yl)butan-1-one:oxygen oxidoreductase (methylamine releasing))
Pseudooksinikotin oksidaza (EC 1.4.3.24, pseudooksinikotinska oksidaza) je enzim sa sistematskim imenom 4-(metilamino)-1-(piridin-3-il)butan-1-on:kiseonik oksidoreduktaza (oslobađa metilamin).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Pseudooksinikotin oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.3.24 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4-(metilamino)-1-(piridin-3-il)butan-1-on + H2O + O2 4-okso-4-(piridin-3-il)butanal + metilamin +H2O2
Ovaj enzim sadrži jedan nekovalentno vezani FAD molekul po dimeru. Ovaj enzim je izolovan iz zemljišne bakterije Pseudomonas sp. HZN6. On učestvuje u nikotinskoj degradaciji.
Reference uredi
- ↑ Qiu, J., Ma, Y., Wen, Y., Chen, L., Wu, L. and Liu, W. (2012). „Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine”. Appl. Environ. Microbiol. 78: 2154-2160. PMID 22267672.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.