D14-sterol reduktaza
(Preusmjereno sa stranice 4,4-dimetil-5alfa-holesta-8,24-dien-3beta-ol:NADP+ Delta14-oksidoreduktaza)
D14-sterol reduktaza (EC 1.3.1.70, D14-sterolna reduktaza) je enzim sa sistematskim imenom 4,4-dimetil-5alfa-holesta-8,24-dien-3beta-ol:NADP+ Delta14-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| D14-sterol reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.70 | ||||||||
| CAS broj | 69403-07-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4,4-dimetil-5alfa-holesta-8,24-dien-3beta-ol + NADP+ 4,4-dimetil-5alfa-holesta-8,14,24-trien-3beta-ol + NADPH + H+
Ovaj enzim deluje na opseg steroida sa 14(15)-dvostrukom vezom.
Reference uredi
- ↑ Bottema, C.K. and Parks, L.W. (1978). „Δ14-Sterol reductase in Saccharomyces cerevisiae”. Biochim. Biophys. Acta 531: 301-307. PMID 32908.
- ↑ Paik, Y.K., Trzaskos, J.M., Shafice, A. and Gaylor, J.L. (1984). „Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent Δ8,14-steroid 14-reductase”. J. Biol. Chem. 259: 13413-13423. PMID 6444198.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.