3b-hidroksi-5a-steroid dehidrogenaza
3b-hidroksi-5a-steroid dehidrogenaza (EC 1.1.1.278, 3b-hidroksi-5a-steroidna dehidrogenaza) je enzim sa sistematskim imenom 3beta-hidroksi-5alfa-steroid:NADP+ 3-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3b-hidroksi-5a-steroid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.278 | ||||||||
| CAS broj | 58875-02-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3beta-hidroksi-5alfa-pregnan-20-on + NADP+ 5alfa-pregnan-3,20-dion + NADPH + H+
Reference
uredi- ↑ Lindemann, P. and Luckner, M. (1997). „Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata”. Phytochemistry 46: 507-513.
- ↑ Warneck, H.M. and Seitz, H.U. (1990). „3β-Hydroxysteroid oxidoreductase in suspension cultures of Digitalis lanata EHRH”. Z. Naturforsch. C: Biosci. 45: 963-972. PMID 2291772.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.