3-hidroksi-2-metil-hinolin-4-on 2,4-dioksigenaza
3-hidroksi-2-metil-hinolin-4-on 2,4-dioksigenaza (EC 1.13.11.48, (1H)-3-hidroksi-4-oksohinaldin 2,4-dioksigenaza) je enzim sa sistematskim imenom 3-hidroksi-2-metil-1H-hinolin-4-on 2,4-dioksigenaza (formira CO).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3-hidroksi-2-metil-hinolin-4-on 2,4-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.48 | ||||||||
| CAS broj | 160995-63-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 3-hidroksi-2-metil-1H-hinolin-4-on + O2 N-acetilantranilat + CO
Ovaj enzim ne sadrži metalni centar ili organski kofaktor.
Reference uredi
- ↑ Bauer, I., De Beyer, A., Tsisuaka, B., Fetzner, S. and Lingens, F. (1994). „A novel type of oxygenolytic ring cleavage: 2,4-Oxygenation and decarbonylation of 1H-3-hydroxy-4-oxoquinaldine and 1H-3-hydroxy-4-oxoquinoline”. FEMS Microbiol. Lett. 117: 299-304.
- ↑ Bauer, I., Max, N., Fetzner, S. and Lingens, F. (1996). „2,4-Dioxygenases catalyzing N-heterocyclic-ring cleavage and formation of carbon monoxide. Purification and some properties of 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase from Arthrobacter sp. Ru61a and comparison with 1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase from Pseudomonas putida 33/1”. Eur. J. Biochem. 240: 576-583. PMID 8856057.
- ↑ Fischer, F., Kunne, S. and Fetzner, S. (1999). „Bacterial 2,4-dioxygenases: new members of the hydrolase-fold superfamily of enzymes functionally related to serine hydrolases”. J. Bacteriol. 181: 5725-5733. PMID 10482514.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.