3-Oksokiselina KoA-transferaza
3-oksokiselina KoA-transferaza (EC 2.8.3.5, 3-oksokiselina koenzim A-transferaza, 3-ketokiselina KoA-transferaza, 3-ketokiselina koenzim A transferaza, 3-okso-KoA transferaza, 3-oksokiselina KoA dehidrogenaza, acetoacetat sukcinil-KoA transferaza, acetoacetil koenzim A-sukcinska tioforaza, sukcinil koenzim A-acetoacetil koenzim A-transferaza, sukcinil-KoA transferaza) je enzim sa sistematskim imenom sukcinil-KoA:3-okso-kiselina KoA-transferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3-oksokiselina KoA-transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.3.5 | ||||||||
| CAS broj | 9027-43-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- sukcinil-KoA + a 3-okso kiselina sukcinat + a 3-oksoacil-KoA
Acetoacetat i u manjoj meri 3-oksopropanoat, 3-oksopentanoat, 3-okso-4-metilpentanoat ili 3-oksoheksanoat mogu da deluju kao akceptori.
Reference
uredi- ↑ Hersh, L.B. and Jencks, W.P. (1967). „Coenzyme A transferase. Kinetics and exchange reactions”. J. Biol. Chem. 242: 3468-3480.
- ↑ Lynen, F. and Ochoa, S. (1953). „Enzymes of fatty acid metabolism”. Biochim. Biophys. Acta 12: 299-314. PMID 13115439.
- ↑ Menon, G.K.K. and Stern, J.R. (1960). „Enzymic synthesis and metabolism of malonyl coenzyme A and glutaryl coenzyme A”. J. Biol. Chem. 235: 3393-3398. PMID 13769479.
- ↑ Stern, J.R., Coon, M.J., del Campillo, A. and Schneider, M.C. (1956). „Enzymes of fatty acid metabolism. IV. Preparation and properties of coenzyme A transferase”. J. Biol. Chem. 221: 15-31. PMID 13345795.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.