3-Hidroksi-16-metoksi-2,3-dihidrotabersonin N-metiltransferaza
3-hidroksi-16-metoksi-2,3-dihidrotabersonin N-metiltransferaza (EC 2.1.1.99, 16-metoksi-2,3-dihidro-3-hidroksitabersoninska metiltransferaza, NMT, 16-metoksi-2,3-dihidro-3-hidroksitabersoninska N-metiltransferaza, S-adenozil-L-metionin:16-metoksi-2,3-dihidro-3-hidroksitabersoninska N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:3-hidroksi-16-metoksi-2,3-dihidrotabersonin N-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3-hidroksi-16-metoksi-2,3-dihidrotabersonin N-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.99 | ||||||||
| CAS broj | 113478-40-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- S-adenozil-L-metionin + 3-hidroksi-16-metoksi-2,3-dihidrotabersonin S-adenozil-L-homocistein + deacetoksivindolin
Ovaj enzim učestvuje u biosintezi vindolina iz tabersonina kod Madagascar periwinkle, Catharanthus roseus.
Reference uredi
- ↑ De Luca, V., Balsevich, J., Tyler, R.T., Eilert, U., Panchuk, B.D. and Kurz, W.G.W. (1986). „Biosynthesis of indole alkaloids - developmental regulation of the biosynthetic-pathway from tabersonine to vindoline in Catharanthus roseus”. J. Plant Physiol. 125: 147-156.
- ↑ De Luca, V. and Cutler, A.J. (1987). „Subcellular localization of enzymes involved in indole alkaloid biosynthesis in Catharanthus roseus”. Plant Physiol. 85: 1099-1102. PMID 16665811.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.