Skimnol sulfotransferaza
(Preusmjereno sa stranice 3'-phosphoadenosine 5'-phosphosulfate:5beta-scymnol sulfotransferase)
Skimnol sulfotransferaza (EC 2.8.2.32, Scymnol sulfotransferase) je enzim sa sistematskim imenom 3'-fosfoadenozin 5'-fosfosulfat:5beta-skimnol sulfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Skimnol sulfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.32 | ||||||||
| CAS broj | 220581-70-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3'-fosfoadenozin 5'-fosfosulfat + 5beta-skimnol adenozin 3',5'-bisfosfat + 5beta-skimnol sulfat
Enzim iz ajkule Heterodontus portusjacksoni može da sulfatira C27 žučnih soli 5beta-skimnol (prirodna žučna so) i 5alfa-ciprinol (žučna so šarana).
Reference uredi
- ↑ Macrides, T.A., Faktor, D.A., Kalafatis, N. and Amiet, R.G. (1994). „Enzymic sulfation of bile salts. Partial purification and characterization of an enzyme from the liver of the shark Heterodontus portusjacksoni that catalyses the sulfation of the shark bile steroid 5β-scymnol”. Comp. Biochem. Physiol. 107: 461-469. PMID 7749614.
- ↑ Pettigrew, N.E., Wright, P.F.A. and Macrides, T.A. (1998). „Investigation of 5β-scymnol sulfotransferase from the kidney and testes of Heterodontus portusjacksoni”. Comp. Biochem. Physiol. 121: 243-249.
- ↑ Pettigrew, N.E., Wright, P.F.A. and Macrides, T.A. (1998). „5β-Scymnol sulfotransferase isolated from the tissues of an Australian shark species”. Comp. Biochem. Physiol. 121: 299-307.
- ↑ Pettigrew, N.E., Wright, P.F.A. and Macrides, T.A. (1998). „5β-scymnol sulfotransferase isolated from the liver of two Australian ray species”. Comp. Biochem. Physiol. 121: 341-348.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.