27S pre-rRNK (guanozin2922-2'-O)-metiltransferaza
27S pre-rRNK (guanozin2922-2'-O)-metiltransferaza (EC 2.1.1.167, Spb1p (gen), YCL054W (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:27S pre-rRNK (guanozin2922-2'-O-)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 27S pre-rRNK (guanozin2922-2'-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.167 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + guanozin2922 u 27S pre-rRNK S-adenozil-L-homocistein + 2'-O-metilguanozin2922 u 27S pre-rRNK
Spb1p je za mesto specifična 2'-O-riboza RNK metiltransferaza, koja katalizuje formiranje 2'-O-metilguanozina2922, univerzalno konzerviranje pozicije katalutičkog centera ribozoma koji je esencijalan za translaciju.
Reference uredi
- ↑ Lapeyre, B. and Purushothaman, S.K. (2004). „Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage”. Mol. Cell 16: 663-669. PMID 15546625.
- ↑ Bonnerot, C., Pintard, L. and Lutfalla, G. (2003). „Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2′-O-ribose methylation of a conserved rRNA position in yeast”. Mol. Cell 12: 1309-1315. PMID 14636587.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.