23S rRNK (guanin1835-N2)-metiltransferaza

23S rRNK (guanin1835-N2)-metiltransferaza
Identifikatori
EC broj	2.1.1.174
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

23S rRNK (guanin¹⁸³⁵-N²)-metiltransferaza (EC 2.1.1.174, ygjO (gen), rlmG (gen), metiltransferaza G ribozomalne RNK velike podjedinice) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (guanin¹⁸³⁵-N²)-metiltransferaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + guanin¹⁸³⁵ u 23S rRNK

\rightleftharpoons

S-adenozil-L-homocistein + N²-metilguanin¹⁸³⁵ u 23S rRNK

Ovaj enzim metiliše 23S rRNK in vitro. Formirane 50S podjedinice nisu supstrat. Enzim specifično metiliše guanin¹⁸³⁵ u N² poziciji unutar 23S rRNK.

Reference uredi

↑ Sergiev, P.V., Lesnyak, D.V., Bogdanov, A.A. and Dontsova, O.A. (2006). „Identification of Escherichia coli m²G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA”. J. Mol. Biol. 364: 26-31. PMID 17010380.

Literatura uredi

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze uredi

MeSH 23S+rRNA+(guanine1835-N2)-methyltransferase

[1] Sergiev, P.V., Lesnyak, D.V., Bogdanov, A.A. and Dontsova, O.A. (2006). „Identification of Escherichia coli m²G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA”. J. Mol. Biol. 364: 26-31. PMID 17010380.

[1]