2-dehidropantolakton reduktaza (A-specific)
2-dehidropantolakton reduktaza (A-specific) (EC 1.1.1.168, 2-oksopantoil laktonska reduktaza, ketopantoil laktonska reduktaza, 2-ketopantoil laktonska reduktaza, 2-dehidropantoil-laktonska reduktaza (A-specifična)) je enzim sa sistematskim imenom (R)-pantolakton:NADP+ oksidoreduktaza (A-specifična).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2-dehidropantolakton reduktaza (A-specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.168 | ||||||||
| CAS broj | 37211-75-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (R)-pantolakton + NADP+ 2-dehidropantolakton + NADPH + H+
Enzim iz kvasca se razlikuje od enzima iz Escherichia coli (EC 1.1.1.214, 2-dehidropantolakton reduktaza (B-specifična)), koji je specifičan za B-stranu NADP+, i u pogledu receptorskih zahteva od EC 1.1.99.26, 3-hidroksicikloheksanonske dehidrogenaze.
Reference
uredi- ↑ King, H.L., Jr. and Wilken, D.R. (1972). „Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase”. J. Biol. Chem. 247: 4689-4695. PMID 4603075.
- ↑ Wilken, D.R., King, H.L., Jr. and Dyar, R.E. (1975). „Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate”. J. Biol. Chem. 250: 2311-2314. PMID 234966.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.