2-dehidro-3-dezoksi-D-glukonat 5-dehidrogenaza
2-dehidro-3-dezoksi-D-glukonat 5-dehidrogenaza (EC 1.1.1.127, 2-keto-3-dezoksiglukonat 5-dehidrogenaza, 2-keto-3-dezoksi-D-glukonat dehidrogenaza, 2-keto-3-dezoksiglukonat (nikotinamid adenin dinukleotid (fosfat)) dehidrogenaza, 2-keto-3-dezoksi-D-glukonat (3-dezoksi-D-glicero-2,5-heksodiulosonska kiselina) dehidrogenaza) je enzim sa sistematskim imenom 2-dehidro-3-dezoksi-D-glukonat:NAD+ 5-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
2-dehidro-3-dezoksi-D-glukonat 5-dehidrogenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.1.1.127 | ||||||||
CAS broj | 37250-56-9 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 2-dehidro-3-dezoksi-D-glukonat + NAD+ (4S)-4,6-dihidroksi-2,5-dioksoheksanoat + NADH + H+
2-dehidro-3-dezoksi-D-glukonatna 5-dehidrogenaza iz Pseudomonas deluje jednako dobro na NAD+ or NADP+, dok su enzimi iz Erwinia chrysanthemi i Escherichia coli specifičniji za NAD+.
Reference uredi
- ↑ Condemine, G., Hugouvieux-Cotte-Pattat, N. and Robert-Baudouy, J. (1984). „An enzyme in the pectolytic pathway of Erwinia chrysanthemi: 3-keto-3-deoxygluconate oxidoreductase”. J. Gen. Microbiol. 130: 2839-2844.
- ↑ Preiss, J. and Ashwell, G. (1963). „Polygalacturonic acid metabolism in bacteria. II. Formation and metabolism of 3-deoxy-D-glycero-2,5-hexodiulosonic acid”. J. Biol. Chem. 238: 1577-1583. PMID 13986017.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.