2-Oksoglutaratna dekarboksilaza
2-Oksoglutaratna dekarboksilaza (EC 4.1.1.71, oksoglutaratna dekarboksilaza, alfa-ketoglutaratna dekarboksilaza, alfa-ketoglutarna dekarboksilaza, pre-2-oksoglutaratna dekarboksilaza, 2-oksoglutaratna karboksilijaza) je enzim sa sistematskim imenom 2-oksoglutarat karboksilijaza (formira sukcinat-semialdehid).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2-Oksoglutaratna dekarboksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 4.1.1.71 | ||||||||
| CAS broj | 37205-42-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 2-oksoglutarat sukcinat semialdehid + CO2
Za dejstvo ovog enzima je neophodan tiamin difosfat.
Reference uredi
- ↑ Shigeoka, S., Onishi, T., Maeda, K., Nakano, Y. and Kitaoka, S. (1986). „Occurrence of thiamin pyrophosphate-dependent 2-oxoglutarate decarboxylase in mitochondria of Euglena gracilis”. FEBS Lett. 195: 43-47.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.