2-Hidroksi-6-oksonona-2,4-diendioatna hidrolaza
2-Hidroksi-6-oksonona-2,4-diendioatna hidrolaza (EC 3.7.1.14, mhpC (gen)) je enzim sa sistematskim imenom (2Z,4E)-2-hidroksi-6-oksona-2,4-dienedioat sukcinilhidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2-Hidroksi-6-oksonona-2,4-diendioatna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.7.1.14 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) (2Z,4E)-2-hidroksi-6-oksonona-2,4-dien-1,9-dioat + H2O (2Z)-2-hidroksipenta-2,4-dienoat + sukcinat
- (2) (2Z,4E,7E)-2-hidroksi-6-oksonona-2,4,7-trien-1,9-dioat + H2O (2Z)-2-hidroksipenta-2,4-dienoat + fumarat
Ovaj enzim katalizuje jedan od koraka u degradaciji fenilpropanoidnih jedinjenja.
Reference uredi
- ↑ Burlingame, R. and Chapman, P.J. (1983). „Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli”. J. Bacteriol. 155: 113-121. PMID 6345502.
- ↑ Burlingame, R.P., Wyman, L. and Chapman, P.J. (1986). „Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation”. J. Bacteriol. 168: 55-64. PMID 3531186.
- ↑ Lam, W. W. Y and Bugg, T. D. H. (1994). „Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage”. J. Chem. Soc., Chem. Commun. 10: 1163-1164.
- ↑ Lam, W.W. and Bugg, T.D. (1997). „Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase”. Biochemistry 36: 12242-12251. PMID 9315862.
- ↑ Ferrández, A., García, J.L. and Díaz, E. (1997). „Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12”. J. Bacteriol. 179: 2573-2581. PMID 9098055.
- ↑ Díaz, E., Ferrández, A. and García, J.L. (1998). „Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12”. J. Bacteriol. 180: 2915-2923. PMID 9603882.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.