2-Halokiselinska dehalogenaza

2-halokiselinska dehalogenaza (EC 3.8.1.2, 2-halokiselinska dehalogenaza (nespecifična), 2-halokiselinska halidohidrolaza (nespecifična), 2-haloalkanoidno kiselinska dehalogenaza, 2-haloalkanoidno kiselinska halidohidrolaza, 2-halokarboksilno kiselinska dehalogenaza II, DL-2-halokiselinska dehalogenaza (nespecifična), L-2-halokiselinska dehalogenaza, L-DEX) je enzim sa sistematskim imenom (S)-2-halokiselina halidohidrolaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

2-halokiselinska dehalogenaza
Identifikatori
EC broj 3.8.1.2
CAS broj 37289-39-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
(S)-2-halokiselina + H2O (R)-2-hidroksikiselina + halid

Ovaj enzim deluje na kiseline sa kratkim lancima, C2 do C4.

Reference

uredi
  1. Goldman, P., Milne, G.W.A. and Keister, D.B. (1968). „Carbon-halogen bond cleavage. 3. Studies on bacterial halidohyrolases”. J. Biol. Chem. 243: 428-434. PMID 5635785. 
  2. Motosugi, M., Esaki, N. and Soda, K. (1982). „Preparation and properties of 2-halo acid dehalogenase from Pseudomonas putida”. Agric. Biol. Chem. 46: 837-838. 
  3. Klages, M., Krauss, S. and Lingens, F. (1983). „2-Haloacid dehalogenase from a 4-chlorobenzoate-degrading Pseudomonas spec. CBS 3”. Hoppe-Seyler's Z. Physiol. Chem. 364: 529-535. PMID 6873881. 
  4. Diez, A., Prieto, M.I., Alvarez, M.J., Bautista, J.M., Garrido, J. and Puyet, A. (1996). „Improved catalytic performance of a 2-haloacid dehalogenase from Azotobacter sp. by ion-exchange immobilisation”. Biochem. Biophys. Res. Commun. 220: 828-833. PMID 8607850. 
  5. Mörsberger, F.-M., Müller, R., Otto, M.K., Lingens, F. and Kulbe, K.D. (1991). „Purification and characterization of 2-halocarboxylic acid dehalogenase II from Pseudomonas spec. CBS 3”. Biol. Chem. Hoppe-Seyler 372: 915-922. PMID 1772590. 
  6. Köhler, R., Brokamp, A., Schwarze, R., Reiting, R.H. and Schmidt, F.R.J. (1998). „Characteristics and DNA-sequence of a cryptic haloalkanoic acid dehalogenase from Agrobacterium tumefaciens RS5”. Curr. Microbiol. 36: 96-101. PMID 9425247. 
  7. Motosugi, K., Esahi, N. and Soda, K. (1982). „Bacterial assimilation of D- and L-2-chloropropionates and occurrence of a new dehalogenase”. Arch. Microbiol. 131: 179-183. PMID 7103659. 
  8. Kurihara, T., Esaki, N. and Soda, K. (2000). „Bacterial 2-haloacid dehalogenases: structures and reaction mechanisms”. J. Mol. Catal., B Enzym. 10: 57-65. 
  9. Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N. (1996). „Bacterial 2-haloacid dehalogenases: Structures and catalytic properties”. Pure Appl. Chem. 68: 2097-2103. 

Literatura

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Spoljašnje veze

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