2,4-Dihlorobenzoil-KoA reduktaza
2,4-dihlorobenzoil-KoA reduktaza (EC 1.3.1.63, reduktaza 2,4-dihlorobenzoil-KoA) je enzim sa sistematskim imenom 4-hlorobenzoil-KoA:NADP+ oksidoreduktaza (halogenacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2,4-dihlorobenzoil-KoA reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.63 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4-hlorobenzoil-KoA + NADP+ + hlorid 2,4-dihlorobenzoil-KoA + NADPH + H+
Ovaj enzim takođe deluje u reverznom smeru, pri čemu fomira deo degradacionog puta 2,4-dihlorobenzoata kod bakterija.
Reference
uredi- ↑ Romanov, V. and Hausinger, R.P. (1996). „NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform bacterium strain NTB-1 via 2,4-dichlorobenzoyl coenzyme A”. J. Bacteriol. 178: 2656-2661. PMID 8626335.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.