16S rRNK (citozin967-C5)-metiltransferaza
16S rRNK (citozin967-C5)-metiltransferaza (EC 2.1.1.176, rsmB (gen), fmu (gen), 16S rRNK m5C967 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:16S rRNK (citozin967-C5)-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 16S rRNK (citozin967-C5)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.176 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + citozin967 u 16S rRNK S-adenozil-L-homocistein + 5-metilcitozin967 u 16S rRNK
Ovaj enzim specifično metiliše citozin967 u C5 poziciji 16S rRNK.
Reference uredi
- ↑ Tscherne, J.S., Nurse, K., Popienick, P., Michel, H., Sochacki, M. and Ofengand, J. (1999). „Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli”. Biochemistry 38: 1884-1892. PMID 10026269.
- ↑ Gu, X.R., Gustafsson, C., Ku, J., Yu, M. and Santi, D.V. (1999). „Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli”. Biochemistry 38: 4053-4057. PMID 10194318.
- ↑ Foster, P.G., Nunes, C.R., Greene, P., Moustakas, D. and Stroud, R.M. (2003). „The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate”. Structure 11: 1609-1620. PMID 14656444.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.