1-hidroksikarotenoid 3,4-desaturaza
1-hidroksikarotenoid 3,4-desaturaza (EC 1.3.99.27, CrtD, hidroksineurosporenska desaturaza, karotenoidna 3,4-dehidrogenaza, 1-hidroksi-karotenoidna 3,4-dehidrogenaza) je enzim sa sistematskim imenom 1-hidroksi-1,2-dihidrolikopen:akceptor oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 1-hidroksikarotenoid 3,4-desaturaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.99.27 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 1-hidroksi-1,2-dihidrolikopen + akceptor 1-hidroksi-3,4-didehidro-1,2-dihidrolikopen + redukovani akceptor
Ovi enzimi iz Rubrivivax gelatinosus i Rhodobacter sphaeroides preferentno deluju na aciklične karotenoide (e.g. 1-hidroksi-1,2-dihidroneurosporen, 1-hidroksi-1,2-dihidrolikopen). Brzina konverzije za 3,4-desaturaciju monocikličnog 1'-hidroksi-1',2'-dihidro-gama-karotena je niža.
Reference
uredi- ↑ Teramoto, M., Rahlert, N., Misawa, N. and Sandmann, G. (2004). „1-Hydroxy monocyclic carotenoid 3,4-dehydrogenase from a marine bacterium that produces myxol”. FEBS Lett. 570: 184-188. PMID 15251462.
- ↑ Steiger, S., Astier, C. and Sandmann, G. (2000). „Substrate specificity of the expressed carotenoid 3,4-desaturase from Rubrivivax gelatinosus reveals the detailed reaction sequence to spheroidene and spirilloxanthin”. Biochem. J. 349: 635-640. PMID 10880364.
- ↑ Albrecht, M., Ruther, A. and Sandmann, G. (1997). „Purification and biochemical characterization of a hydroxyneurosporene desaturase involved in the biosynthetic pathway of the carotenoid spheroidene in Rhodobacter sphaeroides”. J. Bacteriol. 179: 7462-7467. PMID 9393712.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.