1-Dezoksi-D-ksiluloza-5-fosfat sintaza
1-Dezoksi-D-ksiluloza-5-fosfat sintaza (EC 2.2.1.7, 1-dezoksi-D-ksiluloza-5-fosfat piruvat-lijaza (karboksilacija), DXP-sintaza) je enzim sa sistematskim imenom piruvat:D-gliceraldehid-3-fosfat acetaldehidtransferaza (dekarboksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 1-Dezoksi-D-ksiluloza-5-fosfat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.2.1.7 | ||||||||
| CAS broj | 202218-79-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- piruvat + D-gliceraldehid 3-fosfat 1-dezoksi-D-ksiluloza 5-fosfat + CO2
Za dejstvo ovog enzima je neophodan tiamin difosfat. Ovaj enzim je deo alternativnog nonmevalonatnog puta za biosintezu terpenoida.
Reference
uredi- ↑ Sprenger, G.A., Schörken, U., Weigert, T., Grolle, S., deGraaf, A.A., Taylor, S.V., Begley, T.P., Bringer-Meyer, S. and Sahm, H. (1997). „Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol”. Proc. Natl. Acad. Sci. USA 94: 12857-12862. PMID 9371765.
- ↑ Kuzuyama, T., Takagi, M., Takahashi, S. and Seto, H. (2000). „Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis”. J. Bacteriol. 182: 891-897. PMID 10648511.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.