(S)-kanadin sintaza
(S)-kanadin sintaza (EC 1.14.21.5, (S)-tetrahidroberberinska sintaza, (S)-tetrahidrokolumbaminska oksidaza (formira metilindioksi-most)) je enzim sa sistematskim imenom (S)-tetrahidrokolumbamin,NADPH:kiseonik oksidoreduktaza (formira metilindioksi-most).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (S)-kanadin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.21.5 | ||||||||
| CAS broj | 114308-22-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (S)-tetrahidrokolumbamin + NADPH + H+ + O2 (S)-kanadin + NADP+ + 2H2O
Ovaj hem-tiolatni enzim (P-450) katalizuje oksidativnu reakciju kojom se ne inkorporira kiseonik u produkt.
Reference
uredi- ↑ Rueffer, M. and Zenk, M.H. (1994). „Canadine synthase from Thalictrum tuberosum cell cultures catalyses the formation of the methylenedioxy bridge in berberine synthesis”. Phytochemistry 36: 1219-1223.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.