(Metionin sintaza) reduktaza
(metionin sintaza) reduktaza (EC 1.16.1.8, metioninska sintaza kob(II)alaminska reduktaza (metilacija), metioninska sintaza reduktaza, (metioninska sintaza)-kobalaminska metiltransferaza (kob(II)alaminska redukcija)) je enzim sa sistematskim imenom (metionin sintaza)-metilkob(I)alamin,S-adenozilhomocistein:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (metionin sintaza) reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.16.1.8 | ||||||||
| CAS broj | 207004-87-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 [metionin sintaza]-metilkob(I)alamin + 2 S-adenozilhomocistein + NADP+ 2 [metionin sintaza]-kob(II)alamin + NADPH + H+ + 2 S-adenozil-L-metionin
Kod ljudi je ovaj enzim flavoprotein koji sadrži FAD i FMN.
Reference
uredi- ↑ Leclerc, D., Wilson, A., Dumas, R., Gafuik, C., Song, D., Watkins, D., Heng, H.H.Q., Rommens, J.M., Scherer, S.W., Rosenblatt, D.S., Gravel, R.A. (1998). „Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria”. Proc. Natl. Acad. Sci. USA 95: 3059-3064. PMID 9501215.
- ↑ Olteanu, H. and Banerjee, R. (2001). „Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation”. J. Biol. Chem. 276: 35558-35563. PMID 11466310.
- ↑ Olteanu, H., Munson, T. and Banerjee, R. (2002). „Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase”. Biochemistry 41: 13378-13385. PMID 12416982.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.