(Citrat (pro-3S)-lijaza) ligaza
(citrat (pro-3S)-lijaza) ligaza (EC 6.2.1.22, citrat lijaza ligaza, citrat lijaza sintetaza, acetat: SH-(acil-nosilac-protein) enzim ligaza (AMP), acetat:HS-citrat lijaza ligaza, acetat:citrat-(pro-3S)-lijaza(tiol-form) ligaza (formira AMP)) je enzim sa sistematskim imenom acetat:(citrat-(pro-3S)-lijaza)(tiol-form) ligaza (formira AMP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (citrat (pro-3S)-lijaza) ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.2.1.22 | ||||||||
| CAS broj | 52660-22-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + acetat + [citrat (pro-3S)-lijaza] (tiolna forma) AMP + difosfat + [citrat (pro-3S)-lijaza] (acetilna forma)
Ovaj enzim zajedno sa EC 2.3.1.49, deacetil-[citrat-(pro-3S)-lijaza] S-acetiltransferazom, acetiluje i aktivira enzim EC 4.1.3.6, citrat (pro-3S)-lijazu.
Reference uredi
- ↑ Antranikian, G. and Gottschalk, G. (1982). „Copurification of citrate lyase and citrate lyase ligase from Rhodopseudomonas gelatinosa and subsequent separation of the two enzymes”. Eur. J. Biochem. 126: 43-47. PMID 7128585.
- ↑ Antranikian, G., Herzberg, C. and Gottschalk, G. (1985). „Covalent modification of citrate lyase ligase from Clostridium sphenoides by phosphorylation/dephosphorylation”. Eur. J. Biochem. 153: 413-420. PMID 3935436.
- ↑ Quentmeier, A. and Antranikian, G. (1985). „Characterization of citrate lyase from Clostridium sporosphaeroides”. Arch. Microbiol. 141: 85-90. PMID 3994485.
- ↑ Schmellenkamp, H. and Eggerer, H. (1974). „Mechanism of enzymic acetylation of des-acetyl citrate lyase”. Proc. Natl. Acad. Sci. USA 71: 1987-1991. PMID 4365579.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.