(R)-limonen 6-monooksigenaza
(Preusmjereno sa stranice (+)-limonenska 6-monooksigenaza)
(R)-limonen 6-monooksigenaza (EC 1.14.13.80, (+)-limonen-6-hidroksilaza, (+)-limonenska 6-monooksigenaza) je enzim sa sistematskim imenom (R)-limonen,NADPH:kiseonik oksidoreduktaza (6-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (R)-limonen 6-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.80 | ||||||||
| CAS broj | 221461-49-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (R)-limonen + NADPH + H+ + O2 (+)-trans-karveol + NADP+ + H2O
Reakcija je stereospecifična sa 95% prinosa (+)-trans-karveola iz (R)-limonena.
Reference uredi
- ↑ Bouwmeester, H.J., Gershenzon, J., Konings, M.C.J.M. and Croteau, R. (1998). „Biosynthesis of the monoterpenes limonene and carvone in the fruit of caraway. I. Demonstration of enzyme activities and their changes with development”. Plant Physiol. 117: 901-912. PMID 9662532.
- ↑ Bouwmeester, H.J., Konings, M.C.J.M., Gershenzon, J., Karp, F. and Croteau, R. (1999). „Cytochrome P-450 dependent (+)-limonene-6-hydroxylation in fruits of caraway (Carum Carvi)”. Phytochemistry 50: 243-248.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.