(+)-Pulegon reduktaza
(+)-Pulegon reduktaza (EC 1.3.1.81, (+)-pulegonska reduktaza) je enzim sa sistematskim imenom (-)-menton:NADP+ oksidoreduktaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (+)-Pulegon reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.81 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) (-)-menton + NADP+ (+)-pulegon + NADPH + H+
- (2) (+)-izomenton + NADP+ (+)-pulegon + NADPH + H+
NADH ne može da zameni NADPH kao reduktant. Delta8,9-dvostruka veza (+)-cis-izopulegona i Delta1,2-dvostruka veza (±)-piperitona nisu supstrati.
Reference
uredi- ↑ Ringer, K.L., McConkey, M.E., Davis, E.M., Rushing, G.W. and Croteau, R. (2003). „Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint”. Arch. Biochem. Biophys. 418: 80-92. PMID 13679086.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.