Želatinaza A
želatinaza-a (EC 3.4.24.24, 72-kDa želatinaza, matriks metaloproteinaza 2, tip IV kolagenaza, 3/4 kolagenaza, matriks metaloproteinaza 5, 72 kDa želatinaža tip A, kolagenaza IV, kolagenaza tip IV, MMP 2, tip IV kolagen metaloproteinaza, tip IV kolagenaza/želatinaza, matriks metaloproteinaza 2) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| želatinaza-a | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Želatinaza A (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.24.24 | ||||||||
| CAS broj | 146480-35-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Razlaganje želatina tipa I i kolagena tipa IV, V, VII, X. Razlaganje kolagenu sličnih sekvenci Pro-Gln-Gli-Ile-Ala-Gly-Gln
Ova endopeptidaza pripada peptidaznoj familiji M10.
Reference
uredi- ↑ Murphy, G., McAlpine, C.G., Poll, C.T. and Reynolds, J.J. (1985). „Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen”. Biochim. Biophys. Acta 831: 49-58. PMID 2994741.
- ↑ Collier, I.E., Wilhelm, S.M., Eisen, A.Z., Marmer, B.L., Grant, G.A., Seltzer, J.L., Kronberger, A., He, C., Bauer, E.A. and Goldberg, G.I. (1988). „H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen”. J. Biol. Chem. 263: 6579-6587. PMID 2834383.
- ↑ Okada, Y., Morodomi, T., Enghild, J.J., Suzuki, K., Yasui, A., Nakanishi, I., Salvesen, G. and Nagase, H. (1990). „Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts-purification and activation of the precursor and enzymic properties”. Eur. J. Biochem. 194: 721-730. PMID 2269296.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.