Ergokalciferol
Ergokalciferol je forma vitamina D, poznata kao vitamin D2. On je u prodaji pod raznim imenima uključujući: Deltalin, Drisdol, i Calcidol. Formira se iz viosterola kad ultraljubičasto svetlo aktivira ergosterol. Gljive su primarni prirodni izvor.
Ergokalciferol | |||
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IUPAC ime |
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Drugi nazivi | Drisdol, Calcidol | ||
Identifikacija | |||
CAS registarski broj | 50-14-6 | ||
PubChem[1][2] | 5280793 | ||
ChemSpider[3] | 4444351 | ||
UNII | VS041H42XC | ||
DrugBank | DB00153 | ||
KEGG[4] | |||
ChEBI | 28934 | ||
ChEMBL[5] | CHEMBL1536 | ||
ATC code | A11 | ||
Jmol-3D slike | Slika 1 | ||
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Svojstva | |||
Molekulska formula | C28H44O | ||
Molarna masa | 396,65 g/mol | ||
Tačka topljenja |
114–118 °C | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
Ergokalciferol se može koristiti kao suplement vitamina D. Jedna klinička smernica iz 2011.[6] ga smatra jednako efektivnim kao i holekalciferol (vitamin D3), koji prirodno proizvodi koža pri izlaganju ultraljubičastom svetlu. Postoji konfliktna evidencija o tome u kojoj meri D2 i D3 imaju slično dejstvo u telu i da li su jednako aktivni. Neke studije sugerišu da je D3 potentniji,[7][8] dok druge iznose jednaku potentnost.[6][9][10]
Uloga u Alchajmerovoj bolesti
urediJedna nedavna studija je utvrdila da veoma niske nivoe vitamina D2 kod pacijenata obolelih od Alchajmerove bolesti.[11]
Reference
uredi- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ 6,0 6,1 Holick, M. F.; Binkley, N. C.; Bischoff-Ferrari, H. A.; Gordon, C. M.; Hanley, D. A.; Heaney, R. P.; Murad, M. H.; Weaver, C. M. (2011). „Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline”. Journal of Clinical Endocrinology & Metabolism 96 (7): 1911. DOI:10.1210/jc.2011-0385. PMID 21646368.
- ↑ Houghton, L.; Vieth, R. (2006). „The case against ergocalciferol (vitamin D2) as a vitamin supplement”. The American Journal of Clinical Nutrition 84 (4): 694–697. PMID 17023693.
- ↑ Trang, H. M.; Cole, D. E.; Rubin, L. A.; Pierratos, A.; Siu, S.; Vieth, R. (1998). „Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2”. The American journal of clinical nutrition 68 (4): 854–858. PMID 9771862.
- ↑ Holick Mf, B. R.; Biancuzzo, R. M.; Chen, T. C.; Klein, E. K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W. i dr.. (2007). „Vitamin D2 is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D”. Journal of Clinical Endocrinology & Metabolism 93 (3): 677–681. DOI:10.1210/jc.2007-2308. PMC 2266966. PMID 18089691.
- ↑ Biancuzzo, R. M.; Young, A.; Bibuld, D.; Cai, M. H.; Winter, M. R.; Klein, E. K.; Ameri, A.; Reitz, R. i dr.. (2010). „Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults”. American Journal of Clinical Nutrition 91 (6): 1621–1626. DOI:10.3945/ajcn.2009.27972. PMC 2869510. PMID 20427729.
- ↑ „Low 25OH Vitamin D2 Levels Found in Untreated Alzheimer's Patients, Compared to Acetylcholinesterase-Inhibitor Treated and Controls” Current Alzheimer Research 9 (9) 2012 DOI:10.2174/156720512803568975 ISSN 1567-2050