UDP-4-amino-4-dezoksi-L-arabinoza formiltransferaza
UDP-4-amino-4-dezoksi-L-arabinoza formiltransferaza (EC 2.1.2.13, UDP-L-Ara4N formiltransferaza, ArnAFT) je enzim sa sistematskim imenom 10-formiltetrahidrofolat:UDP-4-amino-4-dezoksi-beta-L-arabinoza N-formiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-4-amino-4-dezoksi-L-arabinoza formiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.2.13 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 10-formiltetrahidrofolat + UDP-4-amino-4-dezoksi-beta-L-arabinopiranoza 5,6,7,8-tetrahidrofolat + UDP-4-dezoksi-4-formamido-beta-L-arabinopiranoza
Ovu reakciju izvodi bifunkcionalani enzim, koji takođe posreduje reakciju EC 1.1.1.305 [UDP-glukuronska kiselina dehidrogenaza (dekarboksilacija UDP-4-keto-heksauronske kiseline)].
Reference uredi
- ↑ Breazeale, S.D., Ribeiro, A.A., McClerren, A.L. and Raetz, C.R.H. (2005). „A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-amino-4-deoxy-L-arabinose. Identification and function of UDP-4-deoxy-4-formamido-L-arabinose”. J. Biol. Chem. 280: 14154-14167. PMID 15695810.
- ↑ Gatzeva-Topalova, P.Z., May, A.P. and Sousa, M.C. (2005). „Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance”. Biochemistry 44: 5328-5338. PMID 15807526.
- ↑ Williams, G.J., Breazeale, S.D., Raetz, C.R.H. and Naismith, J.H. (2005). „Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis”. J. Biol. Chem. 280: 23000-23008. PMID 15809294.
- ↑ Gatzeva-Topalova, P.Z., May, A.P. and Sousa, M.C. (2005). „Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance”. Structure 13: 929-942. PMID 15939024.
- ↑ Yan, A., Guan, Z. and Raetz, C.R.H. (2007). „An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli”. J. Biol. Chem. 282: 36077-36089. PMID 17928292.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.