Trazodon

Trazodon
(IUPAC) ime
	23-[4-(3-hlorofenil)piperazin-1-il]propil}[1,2,4]triazolo[4,3-a]piridin-3(2H)-on
Klinički podaci
AHFS/Drugs.com	Monografija
MedlinePlus	a681038
Identifikatori
CAS broj	19794-93-5
ATC kod	N06AX05
PubChem	5533
DrugBank	DB00656
ChemSpider	5332
UNII	YBK48BXK30
KEGG	D08626
ChEBI	CHEBI:9654
ChEMBL	CHEMBL621
Hemijski podaci
Formula	C19H22ClN5O
Mol. masa	371,864 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 ; Key: PHLBKPHSAVXXEF-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	visoka
Metabolizam	Hepatički
Poluvreme eliminacije	3-6 sata
Izlučivanje	20% izmet,; 80% urin
Farmakoinformacioni podaci
Trudnoća	C(US)
Pravni status	℞ Prescription only
Način primene	Oralno

Trazodon (Desorel, Oleptro, Benefikat, Depraks, Desirel, Molipaksin, Tombran, Trazorel, Trialodin, Tritiko, i Mesirel) je antidepresiv iz klase serotoninskih antagonista i inhibitora preuzimanja. On je fenilpiperazinsko jedinjenje. Trazodon je isto tako anksiolitik i hipnotik.^[6] Trazodon ima znatno manje izražene nuspojave koje su karakteristične za triciklične antidepresive.

Sinteza uredi

Jedan od sintetičkih puteva je:^[7]^[8]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Haria M, Fitton A, McTavish D (April 1994). „Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders”. Drugs Aging 4 (4): 331–55. DOI:10.2165/00002512-199404040-00006. PMID 8019056.
↑ Palazzo, G.; Silvestrini, B.; 1968, U.S. Patent 3,381,009.
↑ B. Silvestrini, G. Palazzo, DE 164594

Vidi još uredi

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

U.S. National Library of Medicine: Drug Information Portal - Trazodone

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Haria M, Fitton A, McTavish D (April 1994). „Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders”. Drugs Aging 4 (4): 331–55. DOI:10.2165/00002512-199404040-00006. PMID 8019056.

[7] Palazzo, G.; Silvestrini, B.; 1968, U.S. Patent 3,381,009.

[8] B. Silvestrini, G. Palazzo, DE 164594

[6]

[1]

[2]

[3]

[4]

[5]

[7]

[8]