Transportujuća ATPaza ksenobiotika
Transportujuća ATPaza ksenobiotika (EC 3.6.3.44, protein otpornosti na višestruke lekove, MDR protein, P-glikoprotein, protein pleiotropske otpornosti na lekove, PDR protein, ATPaza steroidnog transporta, ATP fosfohidrolaza (eksport steroida)) je enzim sa sistematskim imenom ATP fosfohidrolaza (eksport ksenobiotika).[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Transportujuća ATPaza ksenobiotika | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.3.44 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + H2O + ksenobiotikin ADP + fosfat + ksenobiotikout
Ova ATPaza ABC-tipa je karakteristična po prisustvu dva slična ATP-vezujuća domena.
Reference uredi
- ↑ Bellamy, W.T. (1996). „P-glycoproteins and multidrug resistance”. Annu. Rev. Pharmacol. Toxicol. 36: 161-183. PMID 8725386.
- ↑ Frijters, C.M., Ottenhoff, R., Van Wijland, M.J., Van Nieuwkerk, C., Groen, A.K. and Oude-Elferink, R.P. (1996). „Influence of bile salts on hepatic mdr2 P-glycoprotein expression”. Adv. Enzyme Regul. 36: 351-363. PMID 8869755.
- ↑ Keppler, D., König, J. and Buchler, M. (1997). „The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes”. Adv. Enzyme Regul. 37: 321-333. PMID 9381978.
- ↑ Loe, D.W., Deeley, R.G. and Cole, S.P. (1998). „Characterization of vincristine transport by the Mr 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione”. Cancer Res. 58: 5130-5136. PMID 9823323.
- ↑ van Veen, H.W. and Konings, W.N. (1998). „The ABC family of multidrug transporters in microorganisms”. Biochim. Biophys. Acta 1365: 31-36. PMID 9693718.
- ↑ Griffiths, J.K. and Sansom, C.E. (1998). The Transporter Factsbook. San Diego: Academic Press. str. -.
- ↑ Prasad, R., De Wergifosse, P., Goffeau, A. and Balzi, E. (1995). „Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals”. Curr. Genet. 27: 320-329. PMID 7614555.
- ↑ Nagao, K., Taguchi, Y., Arioka, M., Kadokura, H., Takatsuki, A., Yoda, K. and Yamasaki, M. (1995). „bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily”. J. Bacteriol. 177: 1536-1543. PMID 7883711.
- ↑ Mahé, Y., Lemoine, Y. and Kuchler, K. (1996). „The ATP-binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo”. J. Biol. Chem. 271: 25167-25172. PMID 8810273.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Griffiths, J.K. and Sansom, C.E. (1998). The Transporter Factsbook. San Diego: Academic Press. str. -.