Peptidiltransferaza

(Preusmjereno sa stranice Transpeptidaza)

Peptidiltransferaza (EC 2.3.2.12, transpeptidaza, ribosomalna peptidiltransferaza) je enzim sa sistematskim imenom peptidil-tRNK:aminoacil-tRNK N-peptidiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Peptidiltransferaza
Identifikatori
EC broj 2.3.2.12
CAS broj 9059-29-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
peptidil-tRNK1 + aminoacil-tRNK2 tRNK1 + peptidil(aminoacil-tRNK2)

Ovaj enzim je ribozim. Dve neekvivantne ribonukleoproteinske podjednice deluju na neusaglažen način pri peptidnoj elongaciji.

ReferenceUredi

  1. Rychlik, I. (1966). „Release of lysine peptides by puromycin from polylysyl-transfer ribonucleic acid in the presence of ribosomes”. Biochim. Biophys. Acta 114: 425-427. PMID 5329275. 
  2. Rychlik, I., Cerná, J., Chládek, S., Zemlicka, J. and Haladová, Z. (1969). „Substrate specificity of ribosomal peptidyl transferase: 2′(3′)-O-aminoacyl nucleosides as acceptors of the peptide chain on the amino acid site”. J. Mol. Biol. 43: 13-24. PMID 4897787. 
  3. Traut, R.R. and Monro, R.E. (1964). „The puromycin reaction and its relation to protein synthesis”. J. Mol. Biol. 10: 63-72. 
  4. Voorhees, R.M., Weixlbaumer, A., Loakes, D., Kelley, A.C. and Ramakrishnan, V. (2009). „Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome”. Nat. Struct. Mol. Biol. 16: 528-533. PMID 19363482. 

LiteraturaUredi

Spoljašnje vezeUredi