Trametinib (Mekinist) je antikancerni lek.[4][5][6] On je MEK inhibitor.[7] Lek deluje na MEK1 i MEK2.[7]
Trametinib
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| Klinički podaci
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| AHFS/Drugs.com
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Monografija
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| Identifikatori
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| CAS broj
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871700-17-3
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| ATC kod
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L01XE25
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| PubChem[1][2]
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11707110
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| DrugBank
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DB08911
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| ChemSpider[3]
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9881833
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| Hemijski podaci
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| Formula
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C26H23FIN5O4
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| Mol. masa
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615.39
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| SMILES
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eMolekuli & PubHem
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| InChI |
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InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
Key: LIRYPHYGHXZJBZ-UHFFFAOYSA-N  Y |
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| Farmakokinetički podaci
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| Poluvreme eliminacije
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3,9-4,8 dana
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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| Način primene
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Oralno
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Salama AK, Kim KB: Trametinib (GSK1120212) in the treatment of melanoma. Expert Opin Pharmacother. 2013 Apr;14(5):619-27. doi: 10.1517/14656566.2013.770475. Epub 2013 Feb 23. PMID 23432625
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682. edit
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412. edit
- ↑ 7,0 7,1 Trametinib, NCI Drug Dictionary
Literatura
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Spoljašnje veze
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