Torulen dioksigenaza
Torulen dioksigenaza (EC 1.13.11.59, CAO-2, CarT) je enzim sa sistematskim imenom torulen:kiseonik oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Torulen dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.59 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- torulen + O2 4'-apo-beta,psi-karoten-4'-al + 3-metilbut-2-enal
Pretpostavlja se da se 3-metilbut-2-enal formira. Enzim ne može razgrađuje zasićene 3',4'-veze gama-karotena.
Reference uredi
- ↑ Prado-Cabrero, A., Estrada, A.F., Al-Babili, S. and Avalos, J. (2007). „Identification and biochemical characterization of a novel carotenoid oxygenase: elucidation of the cleavage step in the Fusarium carotenoid pathway”. Mol. Microbiol. 64: 448-460. PMID 17493127.
- ↑ Saelices, L., Youssar, L., Holdermann, I., Al-Babili, S. and Avalos, J. (2007). „Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway”. Mol. Genet. Genomics 278: 527-537. PMID 17610084.
- ↑ Estrada, A.F., Maier, D., Scherzinger, D., Avalos, J. and Al-Babili, S. (2008). „Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation”. Fungal Genet. Biol. 45: 1497-1505. PMID 18812228.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.