Aminopirimidna aminohidrolaza

(Preusmjereno sa Tiaminaza)

Tiaminaza (EC 3.5.99.2, tiaminaza II, tenA (gen)) je enzim sa sistematskim imenom 4-amino-5-aminometil-2-metilpirimidin aminohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Tiaminaza
Identifikatori
EC broj 3.5.99.2
CAS broj 9024-80-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
(1) 4-amino-5-aminometil-2-metilpirimidin + H2O 4-amino-5-hidroksimetil-2-metilpirimidin + amonijak
(2) tiamin +H2O 4-amino-5-hidroksimetil-2-metilpirimidin + 5-(2-hidroksietil)-4-metiltiazol

Ovaj enzim učestvuje u regeneraciji tiaminskog pirimidina.

ReferenceUredi

  1. Fujita, A., Nose, Y. and Kuratani, K. (1954). „Second type of bacterial thiaminase”. J. Vitaminol. (Kyoto) 1: 1-7. PMID 13243520. 
  2. Ikehata, H. (1960). „Purification of thiaminase II”. J. Gen. Appl. Microbiol. 6: 30-39. 
  3. Toms, A.V., Haas, A.L., Park, J.H., Begley, T.P. and Ealick, S.E. (2005). „Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II”. Biochemistry 44: 2319-2329. PMID 15709744. 
  4. Benach, J., Edstrom, W.C., Lee, I., Das, K., Cooper, B., Xiao, R., Liu, J., Rost, B., Acton, T.B., Montelione, G.T. and Hunt, J.F. (2005). „The 2.35 Å structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism”. Acta Crystallogr. D Biol. Crystallogr. 61: 589-598. PMID 15858269. 
  5. Jenkins, A.H., Schyns, G., Potot, S., Sun, G. and Begley, T.P. (2007). „A new thiamin salvage pathway”. Nat. Chem. Biol. 3: 492-497. PMID 17618314. 
  6. Jenkins, A.L., Zhang, Y., Ealick, S.E. and Begley, T.P. (2008). „Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis”. Bioorg. Chem. 36: 29-32. PMID 18054064. 
  7. French, J.B., Begley, T.P. and Ealick, S.E. (2011). „Structure of trifunctional THI20 from yeast”. Acta Crystallogr. D Biol. Crystallogr. 67: 784-791. PMID 21904031. 

LiteraturaUredi

Vanjske vezeUredi