Tetrahloroeten reduktivna dehalogenaza
Tetrahloroeten reduktivna dehalogenaza (EC 1.97.1.8, tetrahloroeten reduktaza) je enzim sa sistematskim imenom akceptor:trihloroeten oksidoreduktaza (hlorinacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju:
Tetrahloroeten reduktivna dehalogenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.97.1.8 | ||||||||
CAS broj | 163913-51-7 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- trihloroeten + hlorid + akceptor tetrahloroeten + redukovani akceptor
Ovaj enzim omogućava zagađivaču tetrahloroetenu da podržava bakterijski rast i odgovoran je za uklanjanje brojnih hlorinisanih ugljovodonika posredstvom tog organizma.
Reference uredi
- ↑ Holliger, C, Wohlfarth, G. and Diekert, G. (1998). „Reductive dechlorination in the energy metabolism of anaerobic bacteria”. FEMS Microbiol. Rev. 22: 383-398.
- ↑ Glod, G., Angst, W., Holliger, C. and Schwarzenbach, R.P. (1997). „Corrinoid-mediated reduction of tetrachloroethene, trichloroethene, and trichlorofluoroethene in homogeneous aqueous solution: Reaction kinetics and reaction mechanisms”. Environ. Sci. Technol. 31: 253-260.
- ↑ Neumann, A., Wohlfarth, G. and Diekert, G. (1996). „Purification and characterization of tetrachloroethene reductive dehalogenase from Dehalospirillum multivorans”. J. Biol. Chem. 271: 16515-16519. PMID 8663199.
- ↑ Schumacher, W., Holliger, C., Zehnder, A.J.B. and Hagen, W.R. (1997). „Redox chemistry of cobalamin and iron-sulfur cofactors in the tetrachloroethene reductase of Dehalobacter restrictus”. FEBS Lett. 409: 421-425. PMID 9224702.
- ↑ Schumacher, W. and Holliger, C. (1996). „T'he proton/electron ratio of the menaquinone-dependent electron transport from dihydrogen to tetrachloroethene in "Dehalobacter restrictus"”. J. Bacteriol. 178: 2328-2333. PMID 8636034.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.