Tetrahidrometanopterin

Tetrahidrometanopterin
Identifikacija
PubChem	5459995
ChemSpider	4573696
Jmol-3D slike	Slika 1
SMILES
	O=C2/N=C(/N)NC=1N[C@@H](C)C(NC=12)[C@H](Nc3ccc(cc3)C[C@H](O)[C@H](O)[C@H](O)CO[C@H]4O[C@@H]([C@@H](O)[C@H]4O)COP(=O)(O[C@H](C(=O)O)CCC(=O)O)O)C
InChI
	InChI=1S/C30H45N6O16P/c1-12(21-13(2)33-26-22(34-21)27(44)36-30(31)35-26)32-15-5-3-14(4-6-15)9-16(37)23(41)17(38)10-49-29-25(43)24(42)19(51-29)11-50-53(47,48)52-18(28(45)46)7-8-20(39)40/h3-6,12-13,16-19,21,23-25,29,32,34,37-38,41-43H,7-11H2,1-2H3,(H,39,40)(H,45,46)(H,47,48)(H4,31,33,35,36,44)/t12-,13+,16+,17-,18+,19-,21?,23+,24-,25-,29+/m1/s1 ; Kod: SCBIBGUJSMHIAI-FDLOOEGASA-N InChI=1/C30H45N6O16P/c1-12(21-13(2)33-26-22(34-21)27(44)36-30(31)35-26)32-15-5-3-14(4-6-15)9-16(37)23(41)17(38)10-49-29-25(43)24(42)19(51-29)11-50-53(47,48)52-18(28(45)46)7-8-20(39)40/h3-6,12-13,16-19,21,23-25,29,32,34,37-38,41-43H,7-11H2,1-2H3,(H,39,40)(H,45,46)(H,47,48)(H4,31,33,35,36,44)/t12-,13+,16+,17-,18+,19-,21?,23+,24-,25-,29+/m1/s1; Kod: SCBIBGUJSMHIAI-FDLOOEGABF
Svojstva
Molekulska formula	C30H45N6O16P
Molarna masa	776,682661
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Tetrahidrometanopterin (THMPT, H₄MPT) je koenzim u metanogenezi. On je nosač C1 grupe, koja se redukuje do metil nivoa pre transfera na koenzim M.^[4]

Tetrahidrosarcinapterin (THSPT, H₄SPT) je modifikovana forma THMPT-a, u kojoj je glutamil grupa vezana za 2-hidroksiglutarni kraj.

THMPT je glavna platforma za C1 transformacije uredi

N-Formilmetanofuran donira C1 grupu na N5 mesto pterina i formira se formil-THMPT.^[5] Formil grupa se naknadno intramolekulski kondenzuje i daje metenil- THMPT⁻, koji se zatim redukuje do metilen-THMPT-a.^[6] Metilen-MPT se subsekventno konvertuje, koristeći koenzim F420 kao izvor elektrona, u metil-THMPT, posredstvom F₄₂₀-zavisne metilen-THMPT reduktaze. Metil-THMPT je metil donor na koenzim M, u konverziji posredovanoj metil-THMPT:koenzim M metil-transferazom.^[4]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ ^4,0 ^4,1 Thauer RK (September 1998). „Biochemistry of methanogenesis: a tribute to Marjory Stephenson. 1998 Marjory Stephenson Prize Lecture”. Microbiology 144 (Pt 9): 2377–406. DOI:10.1099/00221287-144-9-2377. PMID 9782487. Arhivirano iz originala na datum 2020-05-17. Pristupljeno 2014-04-11.
↑ Acharya P, Warkentin E, Ermler U, Thauer RK, Shima S (March 2006). „The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes”. J. Mol. Biol. 357 (3): 870–9. DOI:10.1016/j.jmb.2006.01.015. PMID 16466742.
↑ Korbas M, Vogt S, Meyer-Klaucke W, et al. (October 2006). „The iron-sulfur cluster-free hydrogenase (Hmd) is a metalloenzyme with a novel iron binding motif”. J. Biol. Chem. 281 (41): 30804–13. DOI:10.1074/jbc.M605306200. PMID 16887798.

Spoljašnje veze uredi

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[Thauer-4] 4,0 ^4,1 Thauer RK (September 1998). „Biochemistry of methanogenesis: a tribute to Marjory Stephenson. 1998 Marjory Stephenson Prize Lecture”. Microbiology 144 (Pt 9): 2377–406. DOI:10.1099/00221287-144-9-2377. PMID 9782487. Arhivirano iz originala na datum 2020-05-17. Pristupljeno 2014-04-11.

[5] Acharya P, Warkentin E, Ermler U, Thauer RK, Shima S (March 2006). „The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes”. J. Mol. Biol. 357 (3): 870–9. DOI:10.1016/j.jmb.2006.01.015. PMID 16466742.

[Korbas-6] Korbas M, Vogt S, Meyer-Klaucke W, et al. (October 2006). „The iron-sulfur cluster-free hydrogenase (Hmd) is a metalloenzyme with a novel iron binding motif”. J. Biol. Chem. 281 (41): 30804–13. DOI:10.1074/jbc.M605306200. PMID 16887798.

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