TRNK-pseudouridinska sintaza I
(Preusmjereno sa stranice TRNK pseudouridinska sintaza)
TRNK-pseudouridinska sintaza I (EC 5.4.99.12, TruA, tRNK pseudouridinska sintaza I, PSUI, hisT (gen)) je enzim sa sistematskim imenom tRNK-uridin38-40 uracil mutaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
| TRNK-pseudouridinska sintaza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.12 | ||||||||
| CAS broj | 61506-89-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- tRNK uridin38-40 tRNK pseudouridin38-40
Uridilatni ostaci u pozicijama 38, 39 i 40 kod skoro svih tRNK molekula su izomerizovane do pseudouridina.
Reference uredi
- ↑ Hur, S. and Stroud, R.M. (2007). „How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA”. Mol. Cell 26: 189-203. PMID 17466622.
- ↑ Huang, L., Pookanjanatavip, M., Gu, X. and Santi, D.V. (1998). „A conserved aspartate of tRNA pseudouridine synthase is essential for activity and a probable nucleophilic catalyst”. Biochemistry 37: 344-351. PMID 9425056.
- ↑ Kammen, H.O., Marvel, C.C., Hardy, L. and Penhoet, E.E. (1988). „Purification, structure, and properties of Escherichia coli tRNA pseudouridine synthase I”. J. Biol. Chem. 263: 2255-2263. PMID 3276686.
- ↑ Turnbough, C.L., Jr., Neill, R.J., Landsberg, R. and Ames, B.N. (1979). „Pseudouridylation of tRNAs and its role in regulation in Salmonella typhimurium”. J. Biol. Chem. 254: 5111-5119. PMID 376505.
- ↑ Zhao, X. and Horne, D.A. (1997). „The role of cysteine residues in the rearrangement of uridine to pseudouridine catalyzed by pseudouridine synthase I”. J. Biol. Chem. 272: 1950-1955. PMID 8999885.
- ↑ Foster, P.G., Huang, L., Santi, D.V. and Stroud, R.M. (2000). „The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I”. Nat. Struct. Biol. 7: 23-27. PMID 10625422.
- ↑ Dong, X., Bessho, Y., Shibata, R., Nishimoto, M., Shirouzu, M., Kuramitsu, S. and Yokoyama, S. (2006). „Crystal structure of tRNA pseudouridine synthase TruA from Thermus thermophilus HB8”. RNA Biol. 3: 115-122. PMID 17114947.
- ↑ Arena, F., Ciliberto, G., Ciampi, S. and Cortese, R. (1978). „Purification of pseudouridylate synthetase I from Salmonella typhimurium”. Nucleic Acids Res. 5: 4523-4536. PMID 370771.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.