TRNK pseudouridinska13 sintaza

TRNK pseudouridinska13 sintaza (EC 5.4.99.27, TruD, YgbO, tRNK PSI13 sintaza, RNK:PSI-sintaza Pus7p, Pus7p, RNK:pseudouridin-sintaza Pus7p, Pus7 protein) je enzim sa sistematskim imenom tRNK-uridin13 uracil mutaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

TRNK pseudouridinska13 sintaza
Identifikatori
EC broj 5.4.99.27
CAS broj 430429-15-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
tRNK uridin13 tRNK pseudouridin13

Pseudouridinska sintaza TruD iz Escherichia coli specifično deluje na uridin13 u tRNK.

ReferenceUredi

  1. Ericsson, U.B., Nordlund, P. and Hallberg, B.M. (2004). "X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold". FEBS Lett. 565: 59-64. PMID 15135053. 
  2. Chan, C.M. and Huang, R.H. (2009). "Enzymatic characterization and mutational studies of TruD—the fifth family of pseudouridine synthases". Arch. Biochem. Biophys. 489: 15-19. PMID 19664587. 
  3. Kaya, Y. and Ofengand, J. (2003). "A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya". RNA 9: 711-721. PMID 12756329. 
  4. Behm-Ansmant, I., Urban, A., Ma, X., Yu, Y.T., Motorin, Y. and Branlant, C. (2003). "The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Ψ-synthase also acting on tRNAs". RNA 9: 1371-1382. PMID 14561887. 
  5. Urban, A., Behm-Ansmant, I., Branlant, C. and Motorin, Y. (2009). "RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:Ψ-synthase Pus7p". J. Biol. Chem. 284: 5845-5858. PMID 19114708. 

LiteraturaUredi

Spoljašnje vezeUredi