TAAR6
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Trag amin-asocirani receptor 6 (TAAR6) je protein koji je kod ljudi kodiran TAAR6 genom.[1][2]
| Trag amin-asocirani receptor 6 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | TAAR6; RP11-295F4.3; TA4; TAR4; TAR6; TRAR4; taR-4; taR-6 | ||||||||||
| Vanjski ID | OMIM: 608923 MGI: 2685074 HomoloGene: 27874 IUPHAR: TAAR6 GeneCards: TAAR6 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 319100 | 215855 | |||||||||
| Ensembl | ENSG00000146383 | ENSMUSG00000045111 | |||||||||
| UniProt | Q96RI8 | Q5QD13 | |||||||||
| RefSeq (mRNA) | NM_175067.1 | NM_001010828.1 | |||||||||
| RefSeq (protein) | NP_778237.1 | NP_001010828.1 | |||||||||
| Lokacija (UCSC) | Chr 6: 132.89 - 132.89 Mb | Chr 10: 23.7 - 23.71 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Funkcija uredi
TAAR6 pripada familiji trag amin-asociranih receptora. Trag amini su endogena aminska jedinjenja koja su hemijski slična sa klasičnim biogenim aminima poput dopamina, norepinefrina, serotonina, i histamina. Trag amini su ranije smatrani 'lažnim transmiterima' koji istiskuju klasične biogene amine iz njihovih skladišta i deluju na transportere na način sličan amfetaminima. Identifikacija moždanih receptora koji su specifični za trag amine ukazuje na činjenicu da oni isto tako samostalno deluju.[3][4]
Reference uredi
- ↑ Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (July 2001). „Trace amines: identification of a family of mammalian G protein-coupled receptors”. Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966–71. DOI:10.1073/pnas.151105198. PMC 55357. PMID 11459929.
- ↑ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). „Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors”. Genomics 85 (3): 372–85. DOI:10.1016/j.ygeno.2004.11.010. PMID 15718104.
- ↑ Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV (October 2004). „Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia”. Am. J. Hum. Genet. 75 (4): 624–38. DOI:10.1086/424887. PMC 1182049. PMID 15329799.
- ↑ „Entrez Gene: TAAR6 trace amine associated receptor 6”.
Literatura uredi
- Cao Q, Martinez M, Zhang J, et al. (1997). „Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees.”. Genomics 43 (1): 1–8. DOI:10.1006/geno.1997.4815. PMID 9226366.
- Kaufmann CA, Suarez B, Malaspina D, et al. (1998). „NIMH Genetics Initiative Millennium Schizophrenia Consortium: linkage analysis of African-American pedigrees.”. Am. J. Med. Genet. 81 (4): 282–9. DOI:10.1002/(SICI)1096-8628(19980710)81:4<282::AID-AJMG2>3.0.CO;2-W. PMID 9674972.
- Borowsky B, Adham N, Jones KA, et al. (2001). „Trace amines: identification of a family of mammalian G protein-coupled receptors.”. Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966–71. DOI:10.1073/pnas.151105198. PMC 55357. PMID 11459929.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6.”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
- Duan J, Martinez M, Sanders AR, et al. (2004). „Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia.”. Am. J. Hum. Genet. 75 (4): 624–38. DOI:10.1086/424887. PMC 1182049. PMID 15329799.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Lindemann L, Ebeling M, Kratochwil NA, et al. (2005). „Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.”. Genomics 85 (3): 372–85. DOI:10.1016/j.ygeno.2004.11.010. PMID 15718104.
- Amann D, Avidan N, Kanyas K, et al. (2006). „The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23.”. Mol. Psychiatry 11 (2): 119–21. DOI:10.1038/sj.mp.4001752. PMID 16189505.