Sulpirid

Sulpirid
(IUPAC) ime
	(±)-5-(aminosulfonil)-N-[(1-etilpirolidin-2-il)metil]-2-metoksibenzamid
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	15676-16-1
ATC kod	N05AL01 N05AL07
PubChem	5355
DrugBank	DB00391
ChemSpider	5162
UNII	7MNE9M8287
KEGG	D01226
ChEMBL	CHEMBL26
Hemijski podaci
Formula	C15H23N3O4S
Mol. masa	341,427 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21) ; Key: BGRJTUBHPOOWDU-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	25–35%
Poluvreme eliminacije	7 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno

Sulpirid (Meresa, Bosnil, Dogmatil, Dolmatil, Eglonil, Modal, Espirid) je tipični antipsihotik iz benzamidne klase koji se uglavnom koristi za tretman psihoze vezane za šizofreniju i kliničku depresiju. Upotreba sulpirida je najzastupljenija u Evropi i Japanu. Levosulpirid je prečišćeni levo-izomer koji je u prodaji u Indiji za slične svrhe. Ovaj lek nije odobren za upotrebu u Sjedinjenim Državama i Kanadi. Sulprid je hemijski i klinički veoma sličan srodnom antipsihotiku amisulpridu.

Hemija uredi

Sulpirid se može sintetitisati iz 5-aminosulfosalicilne kiseline. Metilacicija sa dimetilsulfatom daje 2-metoksi-5-aminosulfonilbenzojevu kiselinu, koja se transformiše u amid koristeći 2-aminometil-1-etilpirolidin kao aminsku komponentu i karbonildiimidazol (CDI) kao kondenzujući agens.^[6]^[7]^[8]^[9]^[10]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ E.L. Engelhardt, Ch.S. Miller, DE 1595915 (1965)
↑ E.L. Engelhardt, Ch.S. Miller, DE 1795723 (1965)
↑ E.L. Engelhardt, M.L. Thominet, U.S. Patent 3.342.826 (1969)
↑ G. Bulteau, J. Acher, U.S. Patent 4.077.976 (1978)
↑ F. Mauri, DE 2903891 (1979)

Vidi još uredi

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] E.L. Engelhardt, Ch.S. Miller, DE 1595915 (1965)

[7] E.L. Engelhardt, Ch.S. Miller, DE 1795723 (1965)

[8] E.L. Engelhardt, M.L. Thominet, U.S. Patent 3.342.826 (1969)

[9] G. Bulteau, J. Acher, U.S. Patent 4.077.976 (1978)

[10] F. Mauri, DE 2903891 (1979)

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