Spiramid (AMI-193) je selektivni antagonist 5-HT2A, 5-HT1A, i D2 receptor. On ima neznatan afinitet za 5-HT2C receptor.[3][4][5]
Spiramid
|
| (IUPAC) ime
|
| 8-[3-(4-Fluorofenoksi)propil]-1-fenil-1,3,8-triazaspiro[4,5]dekan-4-o
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| Klinički podaci
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| Identifikatori
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| CAS broj
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510-74-7
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| ATC kod
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nije dodeljen
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| PubChem[1][2]
|
68186
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| UNII
|
471LF4O004  Y
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| Hemijski podaci
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| Formula
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C22H27FN3O2
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| Mol. masa
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384,466 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27) Y
Key: FJUKDAZEABGEIH-UHFFFAOYSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
|
?
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| Pravni status
|
|
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Czoty PW, Howell LL (October 2000). „Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey”. Pharmacology, Biochemistry, and Behavior 67 (2): 257–64. DOI:10.1016/S0091-3057(00)00321-X. PMID 11124389.
- ↑ Luparini MR, Garrone B, Pazzagli M, Pinza M, Pepeu G (November 2004). „A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone”. Progress in Neuro-psychopharmacology & Biological Psychiatry 28 (7): 1117–27. DOI:10.1016/j.pnpbp.2004.05.046. PMID 15610924.
- ↑ Hamada K, Yoshida M, Isayama H, Yagi Y, Kanazashi S, Kashihara Y, Takeuchi K, Yamaguchi I (November 2007). „Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice”. Journal of Pharmacological Sciences 105 (3): 240–50. DOI:10.1254/jphs.FP0071049. PMID 17965538.
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