Somatostatinski receptor 4

edit

Somatostatinski receptor tip 4 je protein koji je kod čoveka kodiran SSTR4 genom.

Somatostatinski receptor 4
Identifikatori
Simboli	SSTR4;
Vanjski ID	OMIM: 182454 MGI: 105372 HomoloGene: 20286 IUPHAR: sst4 GeneCards: SSTR4 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost somatostatinskog receptora • aktivnost melanin-koncentrujućeg hormonskog receptora Celularna komponenta • integralno sa ćelijskom membranom • membrana Biološki proces • prenos signala • G-proteinska signalizacija, spregnuta sa ciklično nukleotidnim sekundarnim glasnikom • neuropeptidni signalni put • negativna regulacija ćelijske proliferacije
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	6754	20608
Ensembl	ENSG00000132671	ENSMUSG00000037014
UniProt	P31391	Q8BQ97
RefSeq (mRNA)	NM_001052	NM_009219
RefSeq (protein)	NP_001043	NP_033245
Lokacija (UCSC)	Chr 20: 22.96 - 22.97 Mb	Chr 2: 148.09 - 148.09 Mb
PubMed pretraga	[1]	[2]

Somatostatin deluje na mnogim lokacijama i inhibira oslobađanje hormona i drugih sekretornih proteina. Biološki efekti somatostatina su posredovani familijom G protein-spregnutih receptora čije izražavanje je specifično za pojedina tkiva. SSTR4 u znatnoj meri izražen u mozgu fetusa i odraslih osoba, kao i u plućima.

Vidi isto

• Somatostatinski receptor

Literatura

• Patel YC (1999). „Somatostatin and its receptor family.”. Frontiers in neuroendocrinology 20 (3): 157–98. DOI:10.1006/frne.1999.0183. PMID 10433861. 
• Yamada Y, Post SR, Wang K, et al. (1992). „Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.”. Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. DOI:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068. 
• Demchyshyn LL, Srikant CB, Sunahara RK, et al. (1993). „Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.”. Mol. Pharmacol. 43 (6): 894–901. PMID 8100352. 
• Yasuda K, Espinosa R, Davis EM, et al. (1993). „Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2.”. Genomics 17 (3): 785–6. DOI:10.1006/geno.1993.1410. PMID 8244401. 
• Yamada Y, Kagimoto S, Kubota A, et al. (1993). „Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.”. Biochem. Biophys. Res. Commun. 195 (2): 844–52. DOI:10.1006/bbrc.1993.2122. PMID 8373420. 
• Kaupmann K, Bruns C, Hoyer D, et al. (1993). „Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain.”. FEBS Lett. 331 (1-2): 53–9. DOI:10.1016/0014-5793(93)80296-7. PMID 8405411. 
• Yamada Y, Stoffel M, Espinosa R, et al. (1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.”. Genomics 15 (2): 449–52. DOI:10.1006/geno.1993.1088. PMID 8449518. 
• Xu Y, Song J, Bruno JF, Berelowitz M (1993). „Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4.”. Biochem. Biophys. Res. Commun. 193 (2): 648–52. DOI:10.1006/bbrc.1993.1673. PMID 8512564. 
• Fukusumi S, Kitada C, Takekawa S, et al. (1997). „Identification and characterization of a novel human cortistatin-like peptide.”. Biochem. Biophys. Res. Commun. 232 (1): 157–63. DOI:10.1006/bbrc.1997.6252. PMID 9125122. 
• de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). „Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.”. Genomics 42 (3): 499–506. DOI:10.1006/geno.1997.4763. PMID 9205124. 
• Jaïs P, Terris B, Ruszniewski P, et al. (1997). „Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.”. Eur. J. Clin. Invest. 27 (8): 639–44. DOI:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. 
• Sharma K, Patel YC, Srikant CB (1999). „C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.”. Mol. Endocrinol. 13 (1): 82–90. DOI:10.1210/me.13.1.82. PMID 9892014. 
• Forssell-Aronsson EB, Nilsson O, Bejegård SA, et al. (2000). „111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors.”. J. Nucl. Med. 41 (4): 636–42. PMID 10768564. 
• Zatelli MC, Tagliati F, Taylor JE, et al. (2001). „Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.”. J. Clin. Endocrinol. Metab. 86 (5): 2161–9. DOI:10.1210/jc.86.5.2161. PMID 11344221. 
• Talme T, Ivanoff J, Hägglund M, et al. (2001). „Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.”. Clin. Exp. Immunol. 125 (1): 71–9. DOI:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428. 
• Pasquali D, Notaro A, Esposito D, et al. (2002). „[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]”. Minerva Endocrinol. 26 (3): 175–9. PMID 11753241. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052. 
• Papotti M, Bongiovanni M, Volante M, et al. (2002). „Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.”. Virchows Arch. 440 (5): 461–75. DOI:10.1007/s00428-002-0609-x. PMID 12021920. 

Spoljašnje veze

• „Somatostatin Receptors: sst₄”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
• MeSH somatostatin+receptor+subtype-4