Sfingomijelinska fosfodiestaraza
Sfingomijelinska fosfodiestaraza (EC 3.1.4.12, neutralna sfingomijelinaza) je enzim sa sistematskim imenom sfingomielin holinfosfohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sfingomijelinska fosfodiestaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 3.1.4.12 | ||||||||
| CAS broj | 9031-54-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- [[sfingomijelin] + H2O keramid + fosfoholin
Ovaj enzim ima neznatnu aktivnost na fosfatidilholinu.
Reference uredi
- ↑ Barnholz, Y., Roitman, A. and Gatt, S. (1966). „Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain”. J. Biol. Chem. 241: 3731-3737. PMID 5916388.
- ↑ Chatterjee, S. and Ghosh, N. (1989). „Neutral sphingomyelinase from human urine. Purification and preparation of monospecific antibodies”. J. Biol. Chem. 264: 12554-12561. PMID 2545711.
- ↑ Heller, M. and Shapiro, B. (1966). „Enzymic hydrolysis of sphingomyelin by rat liver”. Biochem. J. 98: 763-769. PMID 5911524.
- ↑ Kanfer, J.N., Young, O.M., Shapiro, D. and Brady, R.O. (1966). „The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue”. J. Biol. Chem. 241: 1081-1084. PMID 5933867.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.