Setiptilin
Setiptilin (Tecipul, teciptilin) je tetraciklični antidepresiv (TeCA) koji deluje kao noradrenergički i specifični serotonergički antidepresiv (NaSSA). Kompanija Močida ga je plasirala na tržište 1989. godine kao lek za tretman depresije u Japanu.[5][6]
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 2-metil-2,3,4,9-tetrahidro-1H-dibenzo[3,4:6,7]ciklohepta[1,2-c]piridin | |||
| Klinički podaci | |||
| AHFS/Drugs.com | Internacionalno ime leka | ||
| Identifikatori | |||
| CAS broj | 57262-94-9 | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 5205 | ||
| ChemSpider[3] | 5016 | ||
| UNII | 7L38105Z6E 
| ||
| KEGG[4] | D08511
| ||
| Hemijski podaci | |||
| Formula | C19H19N | ||
| Mol. masa | 261,36 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | ℞ Prescription only | ||
| Način primene | Oralno | ||
Hemija uredi
Setiptilin sadrži tetracikličnu strukturu. On je analog mijanserina i mirtazapina. Setiptilin je delta(13b,4a),4a-karba-mianserin, dok je mirtazapin 6-aza-mianserin.
Farmakologija uredi
Setiptilin deluje kao inhibitor preuzimanja norepinefrina,[7] antagonist α2-adrenergičkog receptora,[8] i antagonist serotoninskih receptora,[9] 5-HT2A, 5-HT2C, i/ili 5-HT3, kao i inverzni agonist H1 receptor.[7]
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Buschmann, H.; Torrens, A.; Vela, J. M. (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. 1. Wiley VCH. str. 248. ISBN 978-3-527-31058-6.[mrtav link]
- ↑ Swiss Pharmaceutical Society, ur. (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. str. 942. ISBN 978-3-88763-075-1.
- ↑ 7,0 7,1 Niho, T.; Ito, C.; Shibutani, Y.; Hashizume, H.; Yamaguchi, K. (1986). „Pharmacological Properties of MO-8282, a Novel Antidepressant”. Nihon yakurigaku zasshi. Folia Pharmacologica Japonica 88 (4): 309-320. PMID 3792961.
- ↑ Mizota, M.; Oikawa, Y.; Nakayama, K.; Mizuguchi, K.; Takarada, T.; Kojima, M.; Kanehiro, H.; Funato, H. i dr.. (1986). „Pharmacological Studies of MO-8282, a New Antidepressant”. Nihon yakurigaku zasshi. Folia Pharmacologica Japonica 88 (6): 457-466. PMID 2881854.
- ↑ Przegaliński, E.; Baran, L.; Siwanowicz, J.; Rawłów, A. (1986). „The Lack of Antidepressant Properties and a Potent Central Antiserotonin Activity of Org 8282”. Polish Journal of Pharmacology and Pharmacy 38 (4): 377-384. PMID 3774630.
Literatura uredi
- Buschmann, H.; Torrens, A.; Vela, J. M. (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. 1. Wiley VCH. str. 248. ISBN 978-3-527-31058-6.[mrtav link]
